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Doctor Profile - Dr. S. Thanikchalam

Chairman & Director CCC, Professor Emeritus
Dr. S. Thanikchalam


MBBS, MD (Gen.Med),DM (Card), D.Sc (Hon), FIACS

Area(s) of Specialization:

Clinical Cardiology, Preventive Cardiology, Non-Invasive Cardiology, Epidemiological Studies, Clinical Trials & Basic Research on Herbal Medicine


46 Years of Experience

  • Adjunct Professor Madras Indian Institute of Technology (IITM)
  • Director - CEFT
  • Former Dean of Faculties & Vice Chancellor

For Appointment, Call:



  • Results of Total Correction of Tetralogy of Fallot in Twenty-One Cases, JAPI, Vol18, Page nos 585 – 589, 1970 S.C.  Munsi, S. John, T. M. Joseph, D. W. Thomas, B. S. Bhati, I. P. Sukumar, S.  Krishnaswami, J. D. McArthur, S. Thanikachalam & G Cherian
  • Selective Left Atrial Cine Angiography in the recognition of Atrial Thrombus, JAPI, vol. 19, page nos 491 – 494, 1971 G. Cherian, S. C. Munsi, S. Krishnaswami, J. B. McArthur, S. Thanikachalam, P. Sukumar, CJohnson, & S. John
  • Congenital absence of the left pericardium, JAPI, Vol 19. page nos 495 – 497, 1971 S. Thanikachalam, J. D. McArthur, & George Cherian
  • Selective Cine Coronary Arteriography, JAPI, vol19, page nos 759-764, 1971 George Cherian, Susil Cmunsi, J.D. McArthur, I. P. Sukumar, S. Krishnaswami & S. Thanikachalam
  • Right Atrial Thrombus following the closure of Atrial Septal Defect, IHJ, Vol. 26, No 1, page nos. 44-46, 1971 S. Thanikachalam, C. P. Nandakumar, G. Cherian, S. John & S Krishnaswami Lymphatic Drainage of the Heart Muscle and pericardial sac in the Dog, IHJ, Vol. 30, No 5, page nos 287- 292, 1976 S Thanikachalam, P. C. Rajaram, A. Namachivayam, Delangovan, T. R. Viswaanathan & C. Lakshmikanthan.
  • Sub-clinical Diabetic Cardiomyopathy – Assessment by systolic time Intervals, JAPI, Vol. 29, page nos 267 – 272, Pril 1981, S. Thanikachalam, C. Lakshmikanthan, Mohan Viswanathan, R. Alagesan, D Elangovan, A Ramachandran & M Viswanathan
  • M-Mode and Two-Dimensional Echocardiographic features of atrial myxoma, IHJ Vol. 34, No 6, page nos 396-399, 1982 C Lakshmikanthan, R Alagesan, B S Ayyappan, A Tajmul Hussain, S Thanikachalam A Sankaran & D Vaidyanathan
  • Right Ventricular Volume estimation by single plane method – Invitro Cas Study, IHJ, Vol35no 4, page nos218-223,1983S Thanikachalam, G Ravindran, G Jayaraman, T R Vishwanathan, D Elangovan, S Ranjan, C Lakshmikandan & P C Rajaram
  • Color Doppler in Obstructive Valvular Disease, Journal of Echocardiography, Vol10,112 -114, 1988, A review article. Natesan G Pandian, S Thanikachalam, D Elangovan
  • Color Doppler in Regurgitant Lesions, Journal of Echocardiography – 1989, A review article. Natesan G Pandian, S. Thanikachalam, D Elangovan
  • The experience of Mitral balloon valvotomy – Fourth Annual Conference of The Indian College of Cardiology-13th –15th June 1997, Hyderabad.
  • Coronary Angiographic Profile in Diabetics Versus Nondiabetics. Research Society for the Study of Diabetes in India, Madras.12th – 14th December 1997
  • A Case of ball valve thrombus, Echocardiography, A Jrnl of CV Ultrasound & Allied Tech , Vol 16, no 2 page Nos 143-145, 1999 S Thanikachalam, G Sengottuvel, Susan George, M Sampath Kumar, R V Shivakumar, K R Balakrishnan, & J S N Murthy case of Ball Valve Thrombus - Echocardiography – A Jrnl.of CV Ultrasound & Allied Tech. 1999: 16:2.
  • Periodontitis as a Risk Factor for Coronary Heart Disease, A case controlled study. Journal of Clinical periodontology – April-2000, S Thanikachalam, India
  • Article published in the International Journal – the Lancet – “Thrombin – specific anticoagulation with Bivalirudin V/s Heparin in patients receiving fibrinolytic Therapy for acute myocardial infarction”: The Hero- 2 Randomized Trial – December 2001 – S Thanikachalam, India
  • Incidence and risk factors of Asymptomatic First Dose Hypertension with Angiotensin Converting Enzyme Inhibitors in Chronic Heart Failure due to Systolic Dysfunction – Indian Heart Journal, Official publication of The Cardiological Society of India: ORIGINAL ARTICLE – Sadagopan Thanikachalam – March –April 2003 Volume 55, no 2.
  • Is it time redefine the Blood Pressure target for the treatment of Hypertension?-Medicographia-Vol 25,  No.3, 2003, pages – 243 – S Thanikachalam  India
  • The Molecular Aspects of Atherosclerosis, Journal of the atherosclerosis of Physicians of India, Volume 12, pages-153-Feb-2002, S Thanikachalam, India
  • Vascular Endothelium Dysfunction Seeing an Elephant, Journal of the Atherosclerosis of Physician of India, January 2005, S Thanikachalam, India
  • The plain radiographic anticipation of the adequacy of left ventricular size in patients with tetralogy of fallot by studying the level of diaphragmatic domes a new sign.A catheter correlated study of Hundred patients, IJRI,15:1, February 2005, S.Thanikachalam, PC Rajaram, Lakshmikanthan, S Vaidyanathan, N Subramanian
  • Trans-Radial Coronary Angioplasty In Indian Patients – Single Operators Experience, 1st Asian Interventional Cardiovascular Therapeutics, Singapore, 4-6 August 2005
  • Vascular Anatomic Challenges Encountered During Transradial Approach For Coronary Diagnosis And Intervention. 1st Asian Interventional Cardiovascular Therapeutics, Singapore, 4-6 August 2005
  • Ideal Hardware For Selective Coronary Cannulation Using Transradial Approach, 1st Asian Interventional Cardiovascular Therapeutics, Singapore, 4-6 August 2005
  • S. Thanikachalam, Sengottuvelu Gunasekaran, Jain TKallarakkal, Percutaneous Transluminal Coronary Angioplasty by Right Transradial Approach in a Patient with Arteria Lusoria Indian Heart J 2006; 58(4):365-367
  • Thanikachalam et al (2012). Polyphenols in madhumega Cho ora Nam, a Siddha medicine, ameliorates carbohydrate metabolism and oxidative stress in type II diabetic rats. Journal of Ethnopharmacology, 2012, Volume: 142, 331–336
  • Thanikachalam et al (2012). Prevalence of vascular stiffness, a marker of future vascular events in age-matched population in normal population versus hypertension population and diabetic population Circ: 2012, 125, 73-74.
  • Thanikachalam et al (2012). Prevalence of risk factors for coronary artery disease in the middle-income group in South Indian population, Circ: 2012, 125, 7374.
  • Thanikachalam et al (2011). A Comprehensive study on a polyherbal Siddha Compound on Plasma Glucose and Serum Lipids in South Indian Population. Planta Medica, Journal of Medicinal Plant and Natural Product Research, March 2011:77(5):553
  • Thanikachalam et al (2014). Population Study of Urban, Rural and Semiurban Regions for the Detection of Endovascular Disease and Prevalence of Risk Factors and Holistic Intervention Study (PURSE-HIS): Rationale, Study Design and Baseline Characteristics. Accepted in The Global Heart Journal
  • Thanikachalam et al. (2014). Efficacy and Safety Profile of Siddha Compound Madhumega Choornam (MMC) in Type II Diabetic Patients. International Journal for Pharmaceutical Research Scholars, 3(1), 322-329
  • Thanikachalam et al (2014). Venthamarai Chooranam, a Siddha medicine, alleviates hypertension via AT1R and eNOS signaling pathway in renovascular hypertensive rats American. Accepted in Experimental Biology and Medicine
  • Thanikachalam, S. Harivanzan, V. Ramasamy, S. McEniery, C.M. Impact of urban versus rural environment on central blood pressure, aortic stiffness and wave reflections: The PURSE HIS study Artery Research vol. 5 issue 4 December 2011. P. 143-144. DOI: 10.1016/j.artres.2011.10.223. ISSN: 1872-9312.
  • Thanikachalam, M. Bai, S. Harivanzan, V. Shoben, A. Baliga, R.R. Thanikachalam, S. Gender-Specific Plasma Triglyceride/High-Density Lipoprotein Cholesterol Concentration Ratio Levels to identify Insulin Resistance and Associated Cardio-Metabolic Risk Factors in a South Asian Population. Canadian Journal of Cardiology vol. 29 issue 10 October 2013. P. S319-S320 DOI: 10.1016/j.cjca.2013.07.537.ISSN:0828-282X.
  • Principal Components Analysis in a South Asian Population: Cardiovascular Risk Variable Clustering and Obesity AHA Scientific Sessions (Submitted) – 2013

PURSE-HIS Study Publications

  • S. Bai, I. Agustsson, V. Harivanzan, L. Krakoff, and S. Thanikachalam. Age-Dependent Impact of Obesity on Aortic Stiffness Circulation. 2013;128:A16679
  • V. Harivanzan, R. Baliga, W.T. Abraham, S. Thanikachalam. Geographical Location and Gender are Predictors of Elevated High-Sensitive C-Reactive Protein (hsCRP) Levels and the Levels  Strongly Correlate with Metabolic Syndrome (MetS) in a South Asian Population. Arteriosclerosis, Thrombosis, and Vascular Biology 2013;33: A200
  • S. Bai, V. Harivanzan, R. Baliga, W.T. Abraham, S. Thanikachalam. Obesity Is An Independent Predictor Of Arterial Stiffness.  Hypertension 2013; 62: A412
  • S. Bai, A. Shoben, V. Harivanzan, R.R. Baliga, S. Thanikachalam, Gender-Specific Plasma Triglyceride/High-Density Lipoprotein Cholesterol Concentration Ratio Levels to Identify Insulin Resistance and Associated Cardio-Metabolic Risk Factors in a South Asian Population. Canadian Journal of Cardiology 2013; 29: 10, S319-S320.
  • A. Must, M. Begum, V. Hivaarnzan, K. Chui, V. Chomitz, O. Bermudez, S. Thanikachalam. The components of metabolic syndrome in relation to weight status in South Indians.  FASEB J April 9, 2013, 27:1055.15
  • K.K.H. Chui, K. Mahalakshmi, V. Harivanzan, A. Must, O. Bermudez, V. Chomitz, S. Thanikachalam. Association between stressful live events and alcohol consumption among South Indians: findings of a population-based cross-sectional survey.  FASEB J April 9, 2013, 27:845.3
  • V. R. Chomitz, S. SPrabhu, S. Thanikachalam, V. Harivanza, K.K.H. Chui, A. Must, O. Bermudez, Physical activity and sedentary behavior in South Indian adults: Urbanicity, gender, and obesity.  FASEB J April 9, 2013, 27:1055.27


Clinical Research

  • Freedom Trial – TDE PH 304
    Global Multicenter trial for newer treatment modalities in PPH. Freedom UT – 15C Studies    (TDE-PH-302 and TDE – PH-304) conducted united Therapeutics
  • OASIS-5
    An International Randomized Double-Blind Study evaluating the efficacy and safety of fondaparinux versus enoxaparin in the acute treatment of unstable angina / non-ST- Segment elevation MI acute coronary syndromes.
  • OASIS-6
    An International Randomized Study evaluating the efficacy and safety of fondaparinux sodium versus control therapy (And glucose – insulin –potassium infusions versus control) in a broad range of patients with ST-segment elevation acute myocardial infarction.
  • Create Study
    A clinical trial of Reviparin & Metabolic modulation in Acute MI Treatment evaluation A large, simple trial of 7-day treatment with low molecular weight heparin versus Placebo and acute treatment with GIK versus control in patients with suspected acute MI.
  • Hero-2 Study
    An open prospectively Randomized comparison of Hirulog Versus Heparin in patients Receiving Aspirin and Thrombolysis (Streptokinase for the Treatment of Acute Myocardial Infarction (HERO -2)
  • Trust – 402
    “A 12-Week, Multi-Centre, Randomized, Double-Blind, Placebo-Controlled trial of the Safety and Efficacy of Intravenous Remodulin in patients in India with Pulmonary Arterial Hypertension (PAH)” Protocol RIV-PH- 402,403,404, and 405.
  • TDE-PH- 304
    Continuation arm of TDE-PH 302 which is a clinical trail phase III in patients with primary pulmonary hypertension.
  • TRUST STUDY - 403
    It is the continuation of arm of IV Treprostinil in patients with PPH (Phase IV)
    This is a non-International study in patients with ACS. Where single and longitudinal blood draw is taken in patients with ACS. In study A & B no fresh patients are being recruited, Only patient who were enrolled in similar study previously are being given treatment in the continuation phase
    Treatment of Hyponatremia Based on Lixivaptan in NYHA Class III/IV Cardiac Patient Evaluation.


  • Since diabetes plays a significant role for the increased incidence of coronary artery disease and acute coronary syndrome the following studies are undertaken.
  • To study efficacy and safety of Alternate medicine for diabetes mellitus and hypertension which are the two primary risk factors for coronary artery disease.
  • Preclinical evaluation of Madhumega choornam (MMC) to control blood sugar in type 2 diabetes both in-vivo & in-vitro study.
  • Preclinical evaluation of Venthamarai choir AM (VMC) to control blood sugar in type 2 diabetes both in-vivo & in-vitro study.
  • A clinical trial of MMC on randomly selected type 2 diabetes with moderate elevation of blood sugar.
  • Study to be started for comparative evaluation of Metformin and MMC in a double-blind randomized design.

Purse His Study:
“Population Study of Urban, Rural and Semi-urban regions to study the prevalence of risk factors conducive to premature vascular disease and detection of both occult and overt Endovascular disease to intervene in a Holistic manner”. (2007 to till date)
Phase I – 2007 to 2011
Phase II – 2012 – 2015
Phase III – 2015 – March 2017

Awards and Honours:

  • Gold Medal in MD General Medicine
  • Padmashree Awardee
  • National Award by MCI - Dr. B. C. Roy  National Award under Eminent Medical Teacher category - 2003

Other Consultants in Cardiac Care Centre

Cardiac Care Centre

Direct: 044-45928631 (8am-4pm)
Board: 044 - 45928500

Ext.no. 450 / 451 / 454 / 8610

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